erdafitinib
(Balversa®)Balversa®
tablet
erdafitinib
Other Name(s):
Balversa®
Appearance:
tablet
This handout gives general information about this cancer medication.
You will learn:
who to contact for help
what the medication is
how it is given
what to expect while on medication
This handout was created by Ontario Health (Cancer Care Ontario) together with patients and their caregivers who have also gone through cancer treatment. It is meant to help support you through your cancer treatment and answer some of your questions.
This information does not replace the advice of your health care team. Always talk to your health care team about your treatment.
My cancer health care provider is: _____________________________________________
During the day I should contact: _______________________________________________
Evenings, weekends and holidays: _____________________________________________
This page gives general information about this cancer medication.
You will learn:
who to contact for help
what the medication is
how it is given
what to expect while on this medication
This information was created by Ontario Health (Cancer Care Ontario) together with patients and their caregivers who have also gone through cancer treatment. It is meant to help support you through your cancer treatment and answer some of your questions.
This information does not replace the advice of your health care team. Always talk to your health care team about your treatment.
Erdafitinib is used to treat a certain type of cancer in the bladder and urinary tract organs.
Tell your health care team if you have or had significant medical condition(s), especially if you have / had:
kidney, liver problems
vision or eye problems
any allergies.
Remember To:
Tell your health care team about all of the other medications you are taking.
Keep taking other medications that have been prescribed for you, unless you have been told not to by your health care team.
You will have a blood test to check for hepatitis B before starting treatment. See the Hepatitis B and Cancer Medications pamphlet for more information.
This medication is usually taken once a day by mouth. Talk to your health care team about how and when to take your medication.
You may need a mix of tablets of different strengths to get the right dose. Make sure you look at your tablets closely so that you take the right dose.
Swallow the tablets whole with a full glass of water, with or without food.
If you forget to take a dose of your erdafitinib:
If you forget to take a dose, take it as soon as you remember if it is the same day. Then take your next dose at the normal scheduled time.
If you miss a day's dose, do not take extra (double up) to make up for the missed dose. Take your next dose at the normal scheduled time.
If you vomit (throw up) after taking your medication, do NOT take another dose. Take your next dose the next day at the normal time.
Warning: If you take too much of this medication by accident, or if you think a child or a pet may have swallowed your medication, you must call the Ontario Poison Control Center right away at: 1-800-268-9017.
To Prevent or Treat Dry Eyes
To prevent or treat dry eyes, at least every 2 hours while awake your health care team may ask you to use artificial tears or lubricating eye gels/ointments at least every 2 hours while awake during treatment. Talk to your health care team on the product(s) to use and how frequent you need to use them.
This treatment may cause Hand-Foot Syndrome
Hand-foot syndrome is a side-effect of erdafitinib treatment that affects the skin on your hands and the bottoms of your feet. It usually starts with tingling or swelling of your skin. Your skin can become painful, red and numb. In worse cases, your skin may start to peel and you can get blisters or sores. This may start days or weeks after your treatment begins.
You can help to prevent symptoms of hand-foot syndrome by doing these things:
Keep your skin moist, especially in the skin folds.
Gently apply moisturizer cream or lotion to the inside of your hands and bottom of your feet as needed. Choose a fragrance-free cream that contains lanolin (like Bag Balm®, Udderly Smooth®) or urea 10% (like Uremol 10®).
Do not let your hands and feet get too hot. Wash sweat from your skin. Bathe or shower in lukewarm water and gently pat yourself dry.
Do not do activities that cause rubbing or pressure on your skin, like heavy-duty washing, gripping tools, typing, playing musical instruments, and driving.
Wear gloves while cleaning to protect your skin from things like laundry detergent, bleach, cleaning products, and dish soap.
Wear loose fitting clothes and loose fitting, comfortable shoes with cushioned soles. Do not walk in bare feet.
Drink 6–8 glasses of liquids each day unless your health care team told you otherwise.
| DO this while on treatment | DO NOT do this while on treatment | |
|
|
DO check with your health care team before getting any vaccinations, surgery, dental work or other medical procedures.
- DO use a lubricating eye ointment or a tear replacement therapy at least every 2 hours while awake to prevent or treat dry eyes.
Do follow to a low phosphate diet. Ask your health care team for dietary advice.
DO NOT take any other medications, such as vitamins, over-the-counter (non-prescription) drugs or substances, or natural health products without checking with your health care team.
DO NOT start any complementary or alternative therapies, such as acupuncture or homeopathic products, without checking with your health care team.
DO NOT use tobacco products (such as smoking cigarettes or vaping) or drink alcohol while on treatment without talking to your health care team first. Smoking and drinking can make side effects worse and make your treatment not work as well.
DO NOT drive, operate machinery or do any tasks that need you to be alert if you experience eye problems such as blurry vision or having difficulty seeing.
Yes, this medication can interact with other medications, vitamins, foods, traditional medicines and natural health products. Interactions can make this medication not work as well or cause severe side effects.
Tell your health care team about all of your:
- prescription and over-the-counter (non-prescription) medications
- other drugs and substances, such as cannabis/marijuana (medical or recreational)
- natural health products such as vitamins, herbal teas, homeopathic medicines, and other supplements, or traditional medicines
Check with your health care team before starting or stopping any of them.
- Anti-inflammatory medications such as ibuprofen (Advil® or Motrin®), naproxen (Aleve®) or Aspirin®.
- Over-the-counter products such as dimenhydrinate (Gravol®)
- Natural health products such as St. John’s Wort
- Traditional medicines
- Supplements such as vitamin C
- Grapefruit juice
- Alcoholic drinks
- Tobacco
- All other drugs or substances, such as marijuana or cannabis (medical or recreational)
Always check your temperature to see if you have a fever before taking any medications for fever or pain (such as acetaminophen (Tylenol®) or ibuprofen (Advil®)).
Fever can be a sign of infection that may need treatment right away.
If you take these medications before you check for fever, they may lower your temperature and you may not know you have an infection.
How to check for fever:
Keep a digital (electronic) thermometer at home and take your temperature if you feel hot or unwell (for example, chills, headache, mild pain).
You have a fever if your temperature taken in your mouth (oral temperature) is:
38.3°C (100.9°F) or higher at any time
OR
38.0°C (100.4°F) or higher for at least one hour.
If you do have a fever:
Try to contact your health care team. If you are not able to talk to them for advice, you MUST get emergency medical help right away.
Ask your health care team for the Fever pamphlet for more information.
If you do not have a fever but have mild symptoms such as headache or mild pain:
- Ask your health care team about the right medication for you. Acetaminophen (Tylenol®) is a safe choice for most people.
Talk to your health care team before you start taking ibuprofen (Advil®, Motrin®), naproxen (Aleve®) or ASA (Aspirin®), as they may increase your chance of bleeding or interact with your cancer treatment.
Talk to your health care team if you already take low dose aspirin for a medical condition (such as a heart problem). It may still be safe to take.
Talk to your health care team about:
- How this treatment may affect your sexual health
- How this treatment may affect your ability to have a baby, if this applies to you
This treatment may harm an unborn baby. Tell your health care team if you or your partner are pregnant, become pregnant during treatment, or are breastfeeding.
- If there is any chance of pregnancy happening, you and your partner together must use 2 effective forms of birth control at the same time until 3 months after your last treatment dose. Talk to your health care team about which birth control options are best for you.
Do not breastfeed while on this treatment and for 3 months after your last dose.
Do not donate sperm while using erdafitinib and for up to 3 months after your last dose.
Keep erdafitinib tablets in the original packaging at room temperature in a dry place, away from heat and light.
Keep out of sight and reach of children and pets.
Do not throw out any unused erdafitinib tablets/capsules at home. Bring them to your pharmacy to be thrown away safely.
If you are a patient:
Wash your hands before and after touching your oral anti-cancer medication.
Swallow each pill whole. Do not crush or chew your pills.
If you are a caregiver:
Wear nitrile or latex gloves when touching tablets, capsules or liquids.
Wash your hands before putting on your gloves and after taking them off, even if your skin did not touch the oral anti-cancer medication.
Throw out your gloves after each use. Do not re-use gloves.
Do not touch oral anti-cancer medications if you are pregnant or breastfeeding.
If medication gets on your skin:
Wash your skin with a lot of soap and water.
If your skin gets red or irritated, talk to your health care team.
If medication gets in your eyes:
Rinse your eyes with running water right away. Keep water flowing over your open eyes for at least 15 minutes.
The following table lists side effects that you may have when getting _______ treatment. The table is set up to list the most common side effects first and the least common last. It is unlikely that you will have all of the side effects listed and you may have some that are not listed.
Read over the side effect table so that you know what to look for and when to get help. Refer to this table if you experience any side effects while on _______ treatment.
| Very Common Side Effects (50 or more out of 100 people) | |
| Side effects and what to do | When to contact health care team |
Too much phosphate your body High phosphate levels may not cause any symptoms that you can see or feel. Your health care team may order a blood test to check your phosphate levels. In some cases, high phosphate levels may cause:
What to do?
They can increase the amont of phosphate in your blood.
|
Talk to your health care team. Get emergency medical help right away for severe symptoms |
Nail changes What to look for?
|
Talk to your health care team if it does not improve or if it is severe |
Diarrhea What to look for?
What to do? If you have diarrhea:
Ask your health care team for the Diarrhea pamphlet for more information. |
Talk to your health care team if no improvement after 24 hours of taking diarrhea medication or if severe (more than 7 times in one day) |
| Common Side Effects (25 to 49 out of 100 people) | |
| Side effects and what to do | When to contact health care team |
Mouth sores What to look for?
What to do? To help prevent mouth sores:
Ask your health care team for the Oral Care (Mouth Care) pamphlet for more information. |
Talk to your health care team as soon as you notice mouth or lip sores or if it hurts to eat, drink or swallow |
Dry mouth What to look for?
What to do?
See our Mouth Care pamphlet for more information. Talk to your health care team if your dry mouth does not improve or if it is severe. |
Talk to your health care team if it does not improve or if it is severe |
Taste changes What to look for?
What to do?
|
Talk to your health care team if it does not improve or if it is severe |
Rash on your hands and feet (hand-foot syndrome) What to look for?
What to do? To help prevent Hand-foot syndrome:
Ask your health care team for the Hand-foot syndrome pamphlet for more information. |
Talk to your health care team if it does not improve or if it is severe |
Fatigue What to look for?
What to do?
Ask your health care team for the Fatigue pamphlet for more information. |
Talk to your health care team if it does not improve or if it is severe |
Liver problems Your health care team may check your liver function with a blood test. Liver changes do not usually cause any symptoms.
What to do? If you have any symptoms of liver problems, get emergency medical help right away. |
Get emergency medical help right away |
Low appetite What to look for?
Ask your health care team for the Loss of Appetite pamphlet for more information. |
Talk to your health care team if it does not improve or if it is severe |
Constipation What to look for?
What to do? To help prevent constipation:
To help treat constipation:
Ask your health care team for the Constipation Pamphlet for more information. |
Talk to your health care team if it does not improve or if it is severe |
Anemia (low red blood cells) What to look for?
What to do? If your health care team has told you that you have anemia (low red blood cells):
|
Talk to your health care team if it does not improve or if it is severe |
|
Hair thinning or loss What to look for?
What to do?
|
|
Rash; dry, itchy skin What to look for?
What to do? To prevent and treat dry skin:
Rash may be severe in some rare cases and cause your skin to blister or peel. If this happens, get emergency medical help right away. |
Talk to your health care team if it does not improve or if it is severe |
| Less Common Side Effects (10 to 24 out of 100 people) | |
| Side effects and what to do | When to contact health care team |
Eye problems What to look for?
What to do?
|
Contact your health care team as soon as possible (office hours) |
Nausea and vomiting What to look for?
What to do? To help prevent nausea:
If you have nausea or vomiting:
|
Contact your healthcare team if nausea lasts more than 48 hours or vomiting lasts more than 24 hours |
Kidney Problems Your health care team may check for proteins in your urine (pee) and your kidney function regularly with a blood test.You may have blood in your urine. What to look for?
What to do?
To prevent kidney infections:
|
Get emergency medical help right away |
Bladder problems What to look for?
|
Talk to your health care team. Get emergency medical help right away for severe symptoms |
Mild joint, muscle pain or cramps What to look for?
What to do?
Ask your health care team for the Pain pamphlet for more information. |
Talk to your health care team if it does not improve or if it is severe |
Other rare, but serious side effects are possible with this treatment.
If you have any of the following, talk to your cancer health care team or get emergency medical help right away:
- Unusual or heavy nosebleeds, red or pink coloured urine (pee), other unusual bleeding or bleeding that is severe or does not stop
- Severe belly pain, bloating or feeling of fullness and severe constipation
- new skin ulcers, serious skin infections
- pain, swelling and hardening of a vein
For more information on how to manage your symptoms ask your health care provider, or visit: https://www.cancercareontario.ca/symptoms.
September 2026 New drug information sheet
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.
Last Updated: September 24, 2026